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Senior Scientist - Downstream

Company: Yoh, A Day & Zimmermann Company
Location: Castro Valley
Posted on: April 2, 2021

Job Description:

Yoh is a seeking a Sr. Scientist, Downstream to support an Emeryville Area based company. You will have the opportunity to support technical operations via upstream and downstream processes. Responsibilities include protein purification, ATKA/Unicorn technologies and process characterization to name a few.


Title: Sr. Scientist, Downstream

Location: Emeryville, CA

Type: 1 year contract

Industry: Biotechnology/Pharmaceutical

Pay: Competitive, depends on experience

Summary:


The Manufacturing Organization supports the Technical Operations (TechOps) business by compliantly and successfully producing products in line with commercial cGMPs.
The Scientist will be an associate within the MS&T team. The main responsibility of the Scientist is to work with Senior and junior level associates to develop robust Upstream, Downstream or Analytical processes/assays in support of developing and optimizing production processes including process parameter optimization, process characterization, scale-up/tech transfer for large scale product production and support successful implementation of production processes at commercial scale.


Primary responsibilities for role:


Demonstrate ability to develop new techniques, solve complex problems, author technical protocols and reports; and evaluate and implement new instrumentation or process techniques.
Design and takes lead with regards to the execution of laboratory-based studies to screen, optimize, and scale production processes, analyzes and interprets results for novel and scientifically complex experiments, participates in process improvement, development, and qualification activities.
Independently prepares and edits procedures or technical reports of a complex nature, including data interpretation, suitable for regulatory submission.
Provides guidance and may manage work activities of other staff members for specific projects or objectives.
Direct interaction and effective collaboration with project team members, including presenting data at project team meetings; critical review of data; and active involvement in solving technical challenges that arise during development.
Interfaces with other departmental groups such as R&D, Quality Assurance, Regulatory Affairs, Supply Chain and Manufacturing
The individual will be accountable for scientific data review including data integrity verification, statistical analysis and technical report writing.
Strong ability to set and meet deadlines, multitask and prioritize resources based on project needs.
Maintains laboratory facilities and equipment in accordance with company policies and industrial best practices.


Downstream Specific:


Has considerable knowledge and technical expertise in protein purification derived recombinant proteins and monoclonal antibodies.
Lead the efforts for developing and optimizing downstream processes including process parameter optimization, process characterization and scale-up/tech transfer for large scale product production.
Hands-on experience in modern protein purification techniques (chromatography, affinity, ion-exchange, hydrophobic, mixed mode, experience working with AKTA, Unicorn, clarification/filtration, and ultrafiltration/diafiltration) are required.
Execute protocols ranging from resin screening, chromatography, filter sizing and TFF optimization.
Working knowledge of AKTA Avant and Pilot systems and associated software, AKTA Unicorn and Assist software.
Working knowledge and ability to program Unicorn and Assist Plate Reader software or an equivalent.


Education:


Educational degrees must be relevant to position (e.g., Biology, Biochemistry, Chemistry, or Toxicology): PhD +7 years, MS +10 years or BS +12 years' experience in product development, manufacturing science and technology, process engineering within the pharmaceutical industry required


Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.PandoLogic.Category: Science, Keywords: Senior Scientist

Keywords: Yoh, A Day & Zimmermann Company, Castro Valley , Senior Scientist - Downstream, Other , Castro Valley, California

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