Senior Scientist - Downstream
Company: Yoh, A Day & Zimmermann Company
Location: Castro Valley
Posted on: April 2, 2021
Yoh is a seeking a Sr. Scientist, Downstream to support an
Emeryville Area based company. You will have the opportunity to
support technical operations via upstream and downstream processes.
Responsibilities include protein purification, ATKA/Unicorn
technologies and process characterization to name a few.
Title: Sr. Scientist, Downstream
Location: Emeryville, CA
Type: 1 year contract
Pay: Competitive, depends on experience
The Manufacturing Organization supports the Technical Operations
(TechOps) business by compliantly and successfully producing
products in line with commercial cGMPs.
The Scientist will be an associate within the MS&T team. The
main responsibility of the Scientist is to work with Senior and
junior level associates to develop robust Upstream, Downstream or
Analytical processes/assays in support of developing and optimizing
production processes including process parameter optimization,
process characterization, scale-up/tech transfer for large scale
product production and support successful implementation of
production processes at commercial scale.
Primary responsibilities for role:
Demonstrate ability to develop new techniques, solve complex
problems, author technical protocols and reports; and evaluate and
implement new instrumentation or process techniques.
Design and takes lead with regards to the execution of
laboratory-based studies to screen, optimize, and scale production
processes, analyzes and interprets results for novel and
scientifically complex experiments, participates in process
improvement, development, and qualification activities.
Independently prepares and edits procedures or technical reports of
a complex nature, including data interpretation, suitable for
Provides guidance and may manage work activities of other staff
members for specific projects or objectives.
Direct interaction and effective collaboration with project team
members, including presenting data at project team meetings;
critical review of data; and active involvement in solving
technical challenges that arise during development.
Interfaces with other departmental groups such as R&D, Quality
Assurance, Regulatory Affairs, Supply Chain and Manufacturing
The individual will be accountable for scientific data review
including data integrity verification, statistical analysis and
technical report writing.
Strong ability to set and meet deadlines, multitask and prioritize
resources based on project needs.
Maintains laboratory facilities and equipment in accordance with
company policies and industrial best practices.
Has considerable knowledge and technical expertise in protein
purification derived recombinant proteins and monoclonal
Lead the efforts for developing and optimizing downstream processes
including process parameter optimization, process characterization
and scale-up/tech transfer for large scale product production.
Hands-on experience in modern protein purification techniques
(chromatography, affinity, ion-exchange, hydrophobic, mixed mode,
experience working with AKTA, Unicorn, clarification/filtration,
and ultrafiltration/diafiltration) are required.
Execute protocols ranging from resin screening, chromatography,
filter sizing and TFF optimization.
Working knowledge of AKTA Avant and Pilot systems and associated
software, AKTA Unicorn and Assist software.
Working knowledge and ability to program Unicorn and Assist Plate
Reader software or an equivalent.
Educational degrees must be relevant to position (e.g., Biology,
Biochemistry, Chemistry, or Toxicology): PhD +7 years, MS +10 years
or BS +12 years' experience in product development, manufacturing
science and technology, process engineering within the
pharmaceutical industry required
Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer.
All qualified applicants will receive consideration for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, disability, or status as a
protected veteran. Visit
https://www.yoh.com/applicants-with-disabilities to contact us if
you are an individual with a disability and require accommodation
in the application process.PandoLogic.Category: Science, Keywords:
Keywords: Yoh, A Day & Zimmermann Company, Castro Valley , Senior Scientist - Downstream, Other , Castro Valley, California
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