Research Scholar (Post-doctoral Scholar)

Company: NCIRE - The Northern California Institute for Rese
Location: San Francisco
Posted on: May 3, 2025

Job Description:

Research Scholar (Post-doctoral Scholar)Job Category: Research ScholarRequisition Number: RESEA001515Posted: April 14, 2025Employment Type: Full-TimeLocation: San Francisco, CA 94121, USADescriptionPosition Definition:This announcement is for a post-doctoral position in the lab of Raymond Swanson, Dept. of Neurology, University of California, San Francisco (https://www.swansonlab.com/index.html). We are seeking a highly motivated individual to join a small, dedicated group with a focus on translational neuroscience. The incumbent will advance research relevant to Parkinson's disease therapeutics using cell culture, iPSC, and animal models of these disorders. The scholar will lead a research project involving a "gain of function" property of ---synuclein aggregates that presents a novel therapeutic avenue. The scholar will also participate in a project using CRISPR-edited human iPSC-derived dopaminergic neurons to evaluate specific gene variants that render individuals more susceptible to certain environmental causes of Parkinson's disease. Experience with fluorescence microscopy, histology, and immunohistochemistry is strongly preferred. Competitive candidates will have excellent communication and organizational skills and enjoy working with a variety of experimental approaches.Essential Functions:

• Using iPSC-derived neurons, identify genes that modulate susceptibility to toxicant-induced Parkinson's disease.
• Assist in animal studies using AAV-mediated gene downregulation to identify genes that modulate susceptibility to toxicant-induced Parkinson's disease.
• Use live-cell fluorescence microscopy.
• Using cell culture preparations, identify peptides that mitigate the toxicity of alpha-synuclein aggregates.
• Data analysis and manuscript preparation related to the above.Job Requirements:
  • PhD in Neuroscience or related field.
  • Track record of first-author scientific publications.
  • Good familiarity with basic science of neurodegenerative disorders.
  • Experience with fluorescence microscopy, preferably live cell imaging.
  • Experience with cell culture and immunohistochemistry.
  • Excellent communication/collaboration/organizational skills.Working Conditions/Environment:The work environment for this position will include an indoor office and a medical research environment. It may include some minor annoyances such as noise, temperature variations, etc. The incumbent may sustain posture in standing or seated position and may utilize a computer terminal for prolonged periods of time.Compensation:The base wage range for this position is $68,640.00 - $79,639.96 per year. Salary and rank will commensurate with the candidate's qualifications and experience. The wage actually offered to a successful candidate will take into account various relevant and non-discriminatory business factors including, without limitation, the candidate's geographic location, job-related experience, knowledge, and skills, and education, as well as internal equity considerations. A successful candidate may also be eligible to earn additional compensation including bonuses.Equal Opportunity Employer:NCIRE is an Equal Opportunity Employer. This position requires access to United States Government research under the Veterans Administration. Per Veterans Administration regulations surrounding access to US research, qualified US Citizens will be selected over other individuals eligible to work in the United States. If you are eligible to work in the United States, you may still be considered for this position but only if no qualified US citizens apply.Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities.
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Keywords: NCIRE - The Northern California Institute for Rese, Castro Valley , Research Scholar (Post-doctoral Scholar), Other , San Francisco, California