Drug Safety Manager, Drug Safety Compliance and Vendor Oversight

Company: IDEAYA Biosciences
Location: South San Francisco
Posted on: January 27, 2026

Job Description:

Non-Solicitation Policy and Notice to Agencies and Recruiters: IDEAYA's Non-Solicitation Policy strictly prohibits agencies and recruiters from any contact and communication with IDEAYA employees, managers, and leaders to submit unsolicited candidate resumes and/or to solicit business partnerships . Submission of unsolicited candidate resumes by agencies or recruiters with or without a contract in place with IDEAYA Biosciences Inc. will not create any implied obligation. Failure to comply with this policy will result in disqualification from current and future business opportunities with IDEAYA Biosciences. All recruiting and talent agency decisions are strictly managed by the internal IDEAYA Human Resources function. All communication by external agencies and recruiters must be directed to humanresources@ideayabio.com. We ask that you only email your interest once. Job Summary About IDEAYA Biosciences: IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use teamwork to move science forward. For more information, please see www.ideayabio.com. Location: South San Francisco Position Summary: We are seeking a Drug Safety Manager, Compliance and Vendor oversight who supports the oversight of IDEAYA’s Drug Safety activities to ensure adherence to internal SOPs, contractual obligations, and applicable global regulatory requirements. This role provides independent compliance and system oversight for Drug Safety activities performed internally and by all pharmacovigilance vendors working on behalf of IDEAYA, ensuring consistent application of procedures and expectations across vendors operating under Safety Data Exchange Agreements (SDEAs). The role does not perform case processing or system administration. Instead, it focuses on monitoring controls, identifying risks, supporting remediation, and maintaining inspection readiness of the pharmacovigilance system. This position is based in our South San Francisco headquarter offices and required to be onsite four days per week per our company policy. Reporting to: Director, Safety Operations and compliance Job Description What you’ll do: Pharmacovigilance System & Compliance Oversight Oversee compliance of Drug Safety activities adhere to IDEAYA SOPs, work instructions, and applicable regulatory requirements. Monitor consistency of Drug Safety execution across internal teams and vendors. Identify compliance risks, trends, or gaps and escalate findings with clear documentation and recommendations. SOP Governance & Process Alignment Support governance and lifecycle management of Drug Safety SOPs work instructions and related procedures. Ensure procedure remains current, clearly written, and inspection ready aligned with regulatory expectations, and inspection ready. Support SOP training, retraining, and effectiveness checks for internal staff and applicable vendor personnel. Assess alignment between documented procedures and operational practice. Vendor, SDEA & System Oversight Provide consistent compliance oversight across all pharmacovigilance vendors performing activities for IDEAYA. Support oversight of SDEAs to ensure roles, responsibilities, data exchange requirements, and escalation pathways are defined and followed. Monitor vendor compliance with timelines, data quality standards, and documentation requirements using metrics and oversight reviews. In collaboration with IDEAYA GxP IT, support oversight of vendor-used systems supporting Drug Safety activities, including user access controls, access reviews, business continuity and disaster recovery preparedness, and data protection. Review vendor documentation and evidence supporting system and compliance readiness. Document, escalate, and track remediation of vendor- or system-related gaps or risks. Collaborate with Senior Manager, Drug Safety Operations to ensure operational execution aligns with compliance expectations. Deviations, Corrective Actions & Metrics Oversee identification and documentation of internal Drug Safety deviations and non-compliance events. Provide oversight of vendor Quality Events (QEs) documented in accordance with vendor SOPs, ensuring appropriate notification, classification, investigation, and CAPA development meet IDEAYA, GVP, and contractual expectations. Lead review and governance of root cause analyses and CAPAs for vendor QEs, assessing adequacy, timeliness, and effectiveness. Trend and analyze deviations, vendor QEs, and CAPAs to identify recurring or systemic compliance risks and drive risk-based escalation and mitigation. Define, implement, and oversee Drug Safety compliance metrics and KPIs, ensuring consistent monitoring. Audit & Inspection Support Support preparation for regulatory inspections and internal audits related to Drug Safety and pharmacovigilance compliance. Serve as a compliance subject matter expert during inspections, providing support for documentation requests, and evidence generation. Support development, review, and tracking of inspection responses, commitments, and post-inspection remediation activities. Requirements: Education & Experience Bachelor’s degree in life sciences, pharmacy, nursing, public health, or related discipline with 4 years of experience in pharmacovigilance, Drug Safety, or a related regulated environment Required Skills Working knowledge of Drug Safety regulatory requirements Experience supporting SOPs, compliance activities, or quality processes Exposure to vendor-supported or outsourced service models Strong documentation, analytical, and organizational skills Ability to identify risks and escalate issues appropriately Experience supporting audits or inspections Familiarity with Safety Data Exchange Agreements (SDEAs) Experience working with quality or compliance systems Experience collaborating with IT or system owners on compliance topics Compliance-focused mindset Attention to detail and documentation discipline Risk awareness and sound judgment Cross-functional collaboration Ability to influence without direct authority All employees are expected to act with integrity and in full compliance with applicable laws, regulations, and IDEAYA policies, including IDEAYA’s Code of Conduct. Employees must demonstrate good judgement and ethical behavior in all business activities, maintain patient and product safety as a top priority, and report any suspected violations of law or Company policy through appropriate channels Total Rewards Along with our inspiring mission, and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay-for-performance philosophy where employees are eligible to be considered for merit-based salary increases, company discretionary short-term incentive plan participation, and company discretionary stock option awards (based on board approval). Our comprehensive benefits package includes, but is not limited to, medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents), 401k, ESPP, and wellness programs. The expected salary range for the roleof Drug Safety Manager, Compliance and Vendor Oversight is $145,000 - $180,000. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the office location where this open position is located, the final candidates’ experience within their profession, experience in the disease areas we are striving to make an impact in as a company, length of time within the industry, educational background, and performance during the interview process. The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite in the office at the Company’s facilities for training & meetings, with work-from-home flexibility, and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization. IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.

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