Senior Director, Medicinal Chemistry

Company: IDEAYA Biosciences
Location: South San Francisco
Posted on: February 27, 2026

Job Description:

Non-Solicitation Policy and Notice to Agencies and Recruiters: IDEAYA's Non-Solicitation Policy strictly prohibits agencies and recruiters from any contact and communication with IDEAYA employees, managers, and leaders to submit unsolicited candidate resumes and/or to solicit business partnerships . Submission of unsolicited candidate resumes by agencies or recruiters with or without a contract in place with IDEAYA Biosciences Inc. will not create any implied obligation. Failure to comply with this policy will result in disqualification from current and future business opportunities with IDEAYA Biosciences. All recruiting and talent agency decisions are strictly managed by the internal IDEAYA Human Resources function. All communication by external agencies and recruiters must be directed to humanresources@ideayabio.com. We ask that you only email your interest once. Job Summary About IDEAYA Biosciences: IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward. For more information, please see www.ideayabio.com. Location: South San Francisco, CA. Position Summary: We are seeking a talented and highly motivated individual with significant pharmaceutical industry experience to join our multidisciplinary team. The successful candidate will lead a group of medicinal chemists and engage in rational structure-based drug discovery enabled by our computational and structural chemistry group. In addition, the work will include aspects of managing CRO collaborators in the preparation of target molecules and leadership of drug discovery projects. As a member of a dynamic multi-disciplinary team, this person will collaborate with a broad group of scientists within IDEAYA as well as external collaborators. This position is based in our South San Francisco headquarter offices and required to be onsite four days per week per our company policy. Reporting to: Vice President, Medicinal Chemistry Job Description Requirements: Ph.D. in synthetic organic chemistry with 10 to 15 years pharmaceutical medicinal chemistry industrial experience Expert understanding of medicinal chemistry concepts along with strong working knowledge of protein-ligand interactions, conformational and structural analysis to enable creative solutions to drug discovery issues. A strong track record of using structure-based design is essential. Experience in applying molecular modeling methods to structure-based, ligand-based, and fragment-based drug discovery Exceptional knowledge of ADME, physicochemical, biochemical and pharmacological principles as applied to drug discovery High level of creativity and productivity with strong synthetic problem-solving skills Proven leadership capability in cross-functional team setting, either as project team leader or co-lead Excellent oral and written communication skills including ability to present the rationale, data, issues and accomplishments of the team Ability to work closely with senior management Experience managing PhD level reports A strong record of delivering portfolio success and driving projects through to the identification of high quality small-molecule drug candidates Experienced in partnering closely with other functional areas including: computational chemistry, DMPK, in vivo pharmacology, CMC, etc. Excellent awareness of current developments in synthetic and medicinal chemistry, and ability to identify opportunities to advance the science in these fields Strong skills in gathering, documenting, and analyzing competitive information from sources such as patents and meetings and using this information to guide program strategy Significant operational experience in one of the following disciplines: Analytical Chemistry, Computer Aided Drug Design, Structural Biology, Formulation Sciences, in vitro and/or in vivo ADME Strong desire to mentor junior members of the department to increase their medicinal chemistry knowledge and skill set. All employees are expected to act with integrity and in full compliance with applicable laws, regulations, and IDEAYA policies, including IDEAYA’s Code of Conduct. Employees must demonstrate good judgement and ethical behavior in all business activities, maintain patient and product safety as a top priority, and report any suspected violations of law or Company policy through appropriate channels Total Rewards Along with our inspiring mission, and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay-for-performance philosophy where employees are eligible to be considered for merit-based salary increases, company discretionary short-term incentive plan participation, and company discretionary stock option awards (based on board approval). Our comprehensive benefits package includes, but is not limited to, medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents), 401k, ESPP, and wellness programs. The expected salary range for the roleof Senior Director, Medicinal Chemistry is $260,000 - $321,000. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the office location where this open position is located, the final candidates’ experience within their profession, experience in the disease areas we are striving to make an impact in as a company, length of time within the industry, educational background, and performance during the interview process. The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite in the office at the Company’s facilities for training & meetings, with work-from-home flexibility, and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization. IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.

Keywords: IDEAYA Biosciences, Castro Valley , Senior Director, Medicinal Chemistry, Science, Research & Development , South San Francisco, California